Profhilo Injectable: A Dermatologist’s Guide to Glowing Skin

In the world of skincare, topical products like serums and creams are constantly evolving, with new innovations appearing almost every week. In contrast, the injectable skincare segment tends to be more conservative, with fewer new product developments. Major names like Botox and Juvéderm still dominate the market. In fact, many so-called “new products” are simply variations of existing formulas—such as Daxxify, another type of neurotoxin used to smooth wrinkles. However, Profhilo Injectable has recently emerged as a game-changer in this space, offering a fresh alternative to traditional approaches.

However, the arrival of Profhilo has caught the attention of dermatology experts as a true breakthrough. Profhilo is a genuine innovation in the category of hyaluronic acid (HA)-based injectables. HA is a natural substance that helps maintain the skin’s moisture and elasticity. Unlike traditional fillers, Profhilo is not designed to add volume or reshape the face. Instead, it improves overall skin hydration, elasticity, and quality.

Profhilo contains a very high concentration of HA and uses NAHYCO Hybrid Technology, which allows the HA molecules to spread evenly under the skin. This creates a bioremodeling effect—stimulating the skin’s natural production of collagen and elastin without artificially adding volume.

Currently, Profhilo is widely used across Europe and has shown impressive results, especially for patients with early signs of aging such as dullness, sagging, and loss of firmness. Although it has not yet been approved by the FDA in the United States, many practitioners believe profhilo injections will soon become a key part of modern anti aging treatments due to their natural-looking results and minimal recovery time.

What Is Profhilo?

Profhilo is the latest innovation in hyaluronic acid (HA)-based injectable skincare treatments. Unlike traditional fillers such as Juvéderm or Restylane—which are designed to add volume and contour the face—Profhilo’s main goal is to improve overall skin quality. According to Dr. Zeichner, Profhilo works as a skin booster—a new category of aesthetic injectables focused on enhancing skin texture, elasticity, and radiance rather than increasing volume.

The hyaluronic acid in Profhilo is highly concentrated and formulated with a special technology that allows it to spread evenly beneath the skin. This triggers biological activity at the cellular level, stimulating the natural production of collagen and elastin, which typically decline with age. The result is firmer, more hydrated, and naturally refreshed-looking skin.

Dr. Doft describes Profhilo as a long-lasting internal moisturizer that works much deeper than regular creams or serums. Because of this, Profhilo can hydrate areas of the skin that topical products can’t reach, while also providing a mild lifting effect and improving the appearance of fine lines.

Profhilo’s main advantages are its natural-looking results, minimal downtime, and its ability to improve skin structure without altering facial expressions. This is why it’s becoming increasingly popular among dermatologists and patients seeking subtle yet effective rejuvenation.

How Does the Profhilo Injectable Work?

Although Profhilo and traditional hyaluronic acid (HA) fillers like Juvéderm or Restylane are made from the same base ingredient—hyaluronic acid, a natural molecule in the body capable of holding up to 1,000 times its weight in water—their properties differ significantly due to differences in formulation.

Conventional fillers use cross-linked HA, a process where the molecules are chemically bonded to create a thick, gel-like texture. This makes them ideal for adding volume and contouring areas such as the cheeks, chin, or lips.

Profhilo, however, contains non-cross-linked HA. According to Dr. Doft, this makes the texture much more fluid, lightweight, and flexible. As a result, Profhilo spreads evenly beneath the skin rather than staying in one spot like traditional fillers.

Its biological effects are also different. Because it isn’t cross-linked, Profhilo stimulates fibroblast activity in a more natural way, boosting the production of collagen and elastin—proteins essential for firm, elastic skin. The result is smoother, more hydrated, and supple skin from within.

Additionally, Profhilo carries a lower risk of lump formation because it spreads uniformly under the skin. This allows for natural-looking skin rejuvenation without the risk of overfilling or altering facial contours.

The Benefits of the Profhilo Injectable

Profhilo works differently from regular fillers by providing deep hydration while stimulating the skin’s natural collagen production. Dr. Doft compares it to an internal moisturiser that penetrates the dermal layer, resulting in smoother, plumper, brighter, healthier, and more youthful-looking skin.

Some results may be visible shortly after injection due to the immediate boost in skin hydration. However, the full effects typically appear within 2 to 3 weeks, as the HA integrates into the skin and begins triggering a biological response.

One of Profhilo’s key advantages is its long-term benefit. Because the HA is not cross-linked, it effectively stimulates fibroblasts and keratinocytes to produce new collagen and elastin. This improves skin firmness, reduces fine lines, and enhances texture over time.

However, collagen production is a gradual process. Regenerative effects are usually noticeable 3 to 6 months after treatment, making Profhilo ideal for long-term anti-aging care rather than instant results.

Since it works with the skin’s natural renewal process, Profhilo delivers subtle, fresh-looking results without the “overfilled” or artificial appearance often associated with volumising fillers. That’s why it’s a popular choice for patients seeking safe, natural, and science-backed results.

What to Expect

Although Profhilo is an injectable treatment, it’s minimally invasive. Dr. Zeichner notes that the injection technique differs from traditional fillers. Because Profhilo is designed to spread evenly beneath the skin, multiple injection points are used to ensure even distribution in the targeted facial areas.

Typically, the standard protocol involves five injection points on each side of the face, using the BAP (Bio Aesthetic Points) technique. These points are strategically chosen based on facial anatomy to maximise results and minimise the risk of complications.

According to Dr. Doft, two treatment sessions are recommended, spaced one month apart. The first session provides the foundation of hydration and collagen stimulation, while the second strengthens and prolongs the effects.

Because the dosage and placement are highly controlled, downtime is usually minimal. Mild swelling or redness may occur at the injection sites, but these side effects typically subside within 24 to 48 hours.

This gradual approach allows Profhilo to work in a more natural, regenerative way—not simply by adding volume, but by improving the skin’s structure and health. The result is naturally refreshed, firmer skin with minimal risk and maximum comfort.

Potential Side Effects of the Profhilo Injectable

While Profhilo is generally safe, as with any injectable treatment, there are possible mild side effects. Dr. Doft explains that common reactions include minor bruising, swelling, or small lumps at the injection sites. These are temporary and are the body’s normal response to the needle and the injected substance.

Small lumps often form due to HA that hasn’t fully spread under the skin yet, but this usually resolves on its own within one to two weeks without medical intervention.

In rare cases, if swelling, redness, or lumps persist beyond two weeks, it could indicate a more serious reaction such as infection or prolonged inflammation. If this happens, it’s important to consult a certified dermatologist or experienced injector promptly.

Compared to traditional fillers, which are thicker and used for adding volume, Profhilo’s more fluid formula significantly lowers the risk of vascular occlusion or serious complications. However, all injectable treatments should still be performed by qualified medical professionals.

By understanding these possible side effects, patients can better prepare for the procedure and undergo Profhilo treatment safely and confidently—while enjoying long-lasting improvements in skin health and appearance.

The Cost of Profhilo Injections

The cost of Profhilo in the United States is currently unclear, as the product is not yet available on the market. However, like most injectable treatments, the price depends on several key factors. One of the main factors is the number of vials required for each treatment. The amount needed varies from patient to patient, depending on their skin condition and the areas being treated. The more vials used, the higher the total cost.

Another factor that affects pricing is the experience and expertise of the provider performing the procedure. Practitioners with strong reputations or advanced training in dermatology and aesthetics often charge more. Additionally, the location of the clinic plays a role—treatments in major cities or high-cost areas tend to be more expensive than those offered in smaller towns or rural regions.

Profhilo is a relatively new and advanced aesthetic treatment focused on deep hydration, improved skin texture, and collagen stimulation. Given its long-term benefits, its price will likely be in line with other premium injectable procedures. For an accurate estimate, it’s best to consult a licensed provider directly.

Aftercare

Proper aftercare following a Profhilo treatment is essential to ensure optimal results and reduce the risk of side effects. Dr. Zeichner recommends using a cold compress on the injection areas to minimise swelling or bruising. Ice helps soothe the skin and reduce any inflammation that may occur post-treatment. It’s also advised to avoid applying makeup to the treated area for at least 24 hours to prevent clogged pores or irritation.

Heavy physical activity should also be avoided during the first 24 hours. Intense exercise can increase blood flow and worsen swelling or bruising at the injection sites. Alcohol should also be avoided during this period, as it can raise the risk of bruising and slow down healing by dilating blood vessels.

Lastly, avoid extreme temperatures—such as hot saunas, steam rooms, or cold weather exposure—as they may interfere with the skin’s healing process and cause irritation. By following these post-treatment guidelines, as recommended by Dr. Zeichner, you can help maintain skin hydration and support the full benefits of your Profhilo treatment.

Profhilo vs. Skinvive: A Comparison of Two Skin Boosters

In the U.S., another option alongside Profhilo is Skinvive by Juvéderm, a skin booster that also aims to improve skin texture and hydration. While both treatments have similar goals, there are some key differences in their composition and how they work.

Profhilo is an injectable hyaluronic acid treatment that hydrates the skin and stimulates collagen production. It does not contain additives like anaesthetics or specially modified components. Skinvive, on the other hand, includes lidocaine to help reduce discomfort during and after the procedure. Additionally, Skinvive uses a strain of Streptococcus bacteria to assist in synthesising the HA, which may affect how it interacts with the skin.

Dr. Zeichner also notes subtle differences in molecular weight and HA density between the two. Skinvive may also include additional ingredients such as antioxidants or vitamins, which can offer extra protection against free radicals and ageing. However, despite these differences, both products are likely to deliver similar improvements in skin hydration, smoothness, and radiance.

Ultimately, both are effective treatments for enhancing overall skin quality. The choice between Profhilo and Skinvive depends on individual preferences, comfort levels, and specific skin needs.

Conclusion

Profhilo is gaining global attention for its impressive benefits in skin rejuvenation. This hyaluronic acid injectable helps the skin appear smoother, plumper, brighter, and healthier. It acts as a deep, internal moisturiser that improves skin quality from within by enhancing hydration and stimulating collagen production. A key advantage is that it smooths the skin without altering facial shape or adding volume, unlike traditional fillers.

Although Profhilo has not yet been approved by the FDA in the U.S., it is being recognised as a promising and effective skincare treatment. With its natural-looking results and less invasive approach compared to other procedures, Profhilo is becoming an appealing option for those seeking gradual, science-based skin improvement.